Angioedema congress book : 3 tables by Murat Bas

By Murat Bas

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Biochem J 2000; 351: 257 – 264 28 Bae SW, Kim HS, Cha YN, Park YS, Jo SA, Jo I. Rapid increase in endothelial nitric oxide production by bradykinin is mediated by protein kinase A signaling pathway. Biochem Biophys Res Commun 2003; 306: 981 – 987 29 Wang DZ, Chao L, Chao J. Hypotension in transgenic mice overexpressing human bradykinin B2 receptor. Hypertension 1997; 29: 488 – 493 30 Han ED, MacFarlane RC, Mulligan AN, Scafidi J, Davis AE, III. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor.

After binding of an agonist to BKR-2 it is very rapidly desensitized through Ser and Tyr phosphorylation steps [25]. This holds for BKR-1 only to a very limited extent and agonist-mediated phosphorylation has not yet been detected [26]. As described above, the bradykinin receptors belong to the class of G-protein-coupled receptors. When bradykinin binds to BKR-2, phospholipase C (PLC) is activated through a coupling with various G-proteins (Ga, Gi). The activated PLC, in turn, cleaves diacylglycerol (DAG) and inositol triphosphate (IP3) from phospholipids.

Kinin receptors in pain and inflammation. Eur J Pharmacol 2001; 429: 161 – 176 25 Faussner A, Proud D, Town M, Bathon JM. Influence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalisation, and signal transduction. J Biol Chem 1998; 273: 2617 – 2623 26 Blaukat A, Pizard A, Rajerison RM, Alhenc-Gelas F, Müller-Esterl W, Dickie I. Activation of mitogen activated protein kinase by bradykinin B2 receptor is independent of receptor phosphorylation and phosphorylation-triggered internalisation.

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